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The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation

Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of-function mutations in STING have been identified in patients with STING-associated vasculopathy with onset in infancy (...

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Detalles Bibliográficos
Autores principales: Shindo, Ruri, Kuchitsu, Yoshihiko, Mukai, Kojiro, Taguchi, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682468/
https://www.ncbi.nlm.nih.gov/pubmed/36438571
http://dx.doi.org/10.3389/fcell.2022.1037999