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The activity of disease-causative STING variants can be suppressed by wild-type STING through heterocomplex formation
Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from viruses or self-DNA from mitochondria/nuclei. Recently, gain-of-function mutations in STING have been identified in patients with STING-associated vasculopathy with onset in infancy (...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682468/ https://www.ncbi.nlm.nih.gov/pubmed/36438571 http://dx.doi.org/10.3389/fcell.2022.1037999 |