What Makes a Potent Nitrosamine? Statistical Validation of Expert-Derived Structure–Activity Relationships

[Image: see text] The discovery of carcinogenic nitrosamine impurities above the safe limits in pharmaceuticals has led to an urgent need to develop methods for extending structure–activity relationship (SAR) analyses from relatively limited datasets, while the level of confidence required in that S...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas, Robert, Tennant, Rachael E., Oliveira, Antonio Anax F., Ponting, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682520/
https://www.ncbi.nlm.nih.gov/pubmed/36302501
http://dx.doi.org/10.1021/acs.chemrestox.2c00199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682520/
https://www.ncbi.nlm.nih.gov/pubmed/36302501
http://dx.doi.org/10.1021/acs.chemrestox.2c00199

Ejemplares similares