Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay

To identify potent antiviral compounds, we introduced a high-throughput screen platform that can rapidly classify hit compounds according to their target. In our platform, we performed a compound screen using a lentivirus-based pseudovirus presenting a spike protein of coronavirus, and we evaluated...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Kwiwan, Chang, JuOae, Park, Sun-mi, Kim, Jinhee, Jeon, Sangeun, Kim, Dong Hwan, Kim, Young-Eui, Lee, Joo Chan, Im, Somyoung, Jo, Yejin, Min, Ji-Young, Lee, Hanbyeul, Yeom, Minjoo, Seok, Sang-Hyuk, On, Da In, Noh, Hyuna, Yun, Jun-Won, Park, Jun Won, Song, Daesub, Seong, Je Kyung, Kim, Kyung-Chang, Lee, Joo-Yeon, Park, Hyun-Ju, Kim, Seungtaek, Nam, Tae-gyu, Lee, Wonsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682871/
https://www.ncbi.nlm.nih.gov/pubmed/36435212
http://dx.doi.org/10.1016/j.antiviral.2022.105473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682871/
https://www.ncbi.nlm.nih.gov/pubmed/36435212
http://dx.doi.org/10.1016/j.antiviral.2022.105473

Ejemplares similares