Cargando…

Discovery of pentaene polyols by the activation of an enediyne gene cluster: biosynthetic implications for 9-membered enediyne core structures

The identification and characterization of enediyne polyketide synthases (PKSEs) revealed that PKSE-bound polyene is a common intermediate, while its subsequent tailoring steps to enediyne cores remain obscure. Herein, we report pentaene polyols 5–7 and cinnamic acid derivatives 8 and 9 biosynthesiz...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Jian, Tan, Qingwen, Zhu, Saibin, Yan, Xiaohui, Li, Yu, Zhuang, Zhoukang, Zhu, Xiangcheng, Duan, Yanwen, Huang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682884/ https://www.ncbi.nlm.nih.gov/pubmed/36507168 http://dx.doi.org/10.1039/d2sc04379c

Ejemplares similares

A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products
por: Bhardwaj, Minakshi, et al.
Publicado: (2023)

Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S
por: Zhu, Manxiang, et al.
Publicado: (2022)

Strain Prioritization and Genome Mining for Enediyne Natural Products
por: Yan, Xiaohui, et al.
Publicado: (2016)

Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis
por: Ge, Hui-Ming, et al.
Publicado: (2014)

Correction for Bhardwaj et al., A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products
Publicado: (2023)

Thermal Reactivity of Neutral and Oxidized Ferrocenyl-Substituted Enediynes
por: Cinar, Mehmet Emin, et al.
Publicado: (2014)

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads
por: Shen, Ben, et al.
Publicado: (2014)

Cross-π-conjugated enediyne with multitopic metal binding sites
por: Nauroozi, Djawed, et al.
Publicado: (2020)

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis
por: Annaval, Thibault, et al.
Publicado: (2017)

Highly stereocontrolled synthesis of trans-enediynes via carbocupration of fluoroalkylated diynes
por: Konno, Tsutomu, et al.
Publicado: (2012)

A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
por: Cohen, Douglas R., et al.
Publicado: (2017)

Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates
por: Adhikari, Ajeeth, et al.
Publicado: (2021)

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027
por: Chen, Yihua, et al.
Publicado: (2010)

Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits—Synthesis and Antitumor Activity
por: Kadela-Tomanek, Monika, et al.
Publicado: (2017)

Jejucarbosides B–E, Chlorinated Cycloaromatized Enediynes, from a Marine Streptomyces sp.
por: Im, Ji Hyeon, et al.
Publicado: (2023)

Crystal Structure of SgcJ, An NTF2-Like Superfamily Protein Involved in Biosynthesis of the 9-Membered Enediyne Antitumor Antibiotic C-1027
por: Huang, Tingting, et al.
Publicado: (2016)

Ruthenium-Catalyzed Intramolecular [2+2+2] Cycloaddition and Tandem Cross-Metathesis of Triynes and Enediynes
por: Yuan, Wei, et al.
Publicado: (2013)

Angle distortion model for predicting enediyne activation towards Bergman cyclization: an alternate to the distance theory
por: Bhattacharya, Prabuddha, et al.
Publicado: (2022)

An EGFR/HER2-Bispecific and Enediyne-Energized Fusion Protein Shows High Efficacy against Esophageal Cancer
por: Guo, Xiao-Fang, et al.
Publicado: (2014)

A superior drug carrier – aponeocarzinostatin in partially unfolded state fully protects the labile antitumor enediyne
por: Shanmuganathan, Aranganathan, et al.
Publicado: (2009)

Rhodium-catalysed tetradehydro-Diels–Alder reactions of enediynes via a rhodium-stabilized cyclic allene
por: Thadkapally, Srinivas, et al.
Publicado: (2020)

Nucleophilic Addition of Enolates to 1,4-Dehydrobenzene Diradicals Derived from Enediynes: Synthesis of Functionalized Aromatics
por: Shrinidhi, Annadka, et al.
Publicado: (2022)

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19
por: Elshahawi, Sherif I., et al.
Publicado: (2014)

Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027
por: Wang, Lifei, et al.
Publicado: (2009)

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy
por: Xu, Jian, et al.
Publicado: (2015)

A novel enediyne‐integrated antibody–drug conjugate shows promising antitumor efficacy against CD30(+) lymphomas
por: Wang, Rong, et al.
Publicado: (2018)

The Role of Norrish Type-I Chemistry in Photoactive Drugs: An ab initio Study of a Cyclopropenone-Enediyne Drug Precursor
por: Léger, Spencer J., et al.
Publicado: (2020)

Highly selective cross-coupling reactions of 1,1-dibromoethylenes with alkynylaluminums for the synthesis of aryl substituted conjugated enediynes and unsymmetrical 1,3-diynes
por: Wu, Kun, et al.
Publicado: (2022)

The Application of Ribosome Engineering to Natural Product Discovery and Yield Improvement in Streptomyces
por: Zhu, Saibin, et al.
Publicado: (2019)

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus
por: Chang, Chin-Yuan, et al.
Publicado: (2016)

An albumin-binding domain and targeting peptide-based recombinant protein and its enediyne-integrated analogue exhibit directional delivery and potent inhibitory activity on pancreatic cancer with K-ras mutation
por: Sheng, Weijin, et al.
Publicado: (2020)

Use of N-Methylformamide as a Solvent in Indium-Promoted Barbier Reactions en Route to Enediyne and Epoxy Diyne Formation: Comparison of Rate and Stereoselectivity in C−C Bond-Forming Reactions with Water
por: Frimpong, Kwame, et al.
Publicado: (2009)

A bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor and insulin-like growth factor 1 receptor showing enhanced antitumor efficacy against non-small cell lung cancer
por: Guo, Xiao-Fang, et al.
Publicado: (2017)

Identification and Characterization of a New Erythromycin Biosynthetic Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-Producing Halophilic Actinomycete Isolated from Salt Field
por: Chen, Dandan, et al.
Publicado: (2014)

Biosynthetic Potential-Based Strain Prioritization for Natural Product Discovery: A Showcase for Diterpenoid-Producing Actinomycetes
por: Xie, Pengfei, et al.
Publicado: (2014)

TOUCAN: a framework for fungal biosynthetic gene cluster discovery
por: Almeida, Hayda, et al.
Publicado: (2020)

Polyol Pathway Exacerbated Ischemia/Reperfusion-Induced Injury in Steatotic Liver
por: Zhang, Changhe, et al.
Publicado: (2014)

A Genomics Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in Aspergillus ustus
por: Pi, Borui, et al.
Publicado: (2015)

Discovery of Pyranoviolin A and Its Biosynthetic Gene Cluster in Aspergillus violaceofuscus
por: Wei, Xingxing, et al.
Publicado: (2020)

Discovery of an Abundance of Biosynthetic Gene Clusters in Shark Bay Microbial Mats
por: Chen, Ray, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a5i1f0rcqj0v8fdn0dglum4702