Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity

A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres. A collection of 10 compounds was evaluated against glioma c...

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Detalles Bibliográficos
Autores principales: Vala, Ruturajsinh M., Tandon, Vasudha, Nicely, Lynden G., Guo, Luxia, Gu, Yanlong, Banerjee, Sourav, Patel, Hitendra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683054/
https://www.ncbi.nlm.nih.gov/pubmed/36120909
http://dx.doi.org/10.1080/07853890.2022.2123559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683054/
https://www.ncbi.nlm.nih.gov/pubmed/36120909
http://dx.doi.org/10.1080/07853890.2022.2123559

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