Experimental factors that impact Ca(V)1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol

BACKGROUND AND PURPOSE: Ca(V)1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction coupling. Understanding drug action on Ca(V)1.2 channels may inform potential impact on cardiac function. However, literatu...

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Detalles Bibliográficos
Autores principales: Ren, Ming, Randolph, Aaron L., Alvarez-Baron, Claudia, Guo, Donglin, Tran, Phu N., Thiebaud, Nicolas, Sheng, Jiansong, Zhao, Jun, Wu, Wendy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683570/
https://www.ncbi.nlm.nih.gov/pubmed/36417390
http://dx.doi.org/10.1371/journal.pone.0276995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683570/
https://www.ncbi.nlm.nih.gov/pubmed/36417390
http://dx.doi.org/10.1371/journal.pone.0276995

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