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Experimental factors that impact Ca(V)1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol
BACKGROUND AND PURPOSE: Ca(V)1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction coupling. Understanding drug action on Ca(V)1.2 channels may inform potential impact on cardiac function. However, literatu...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683570/ https://www.ncbi.nlm.nih.gov/pubmed/36417390 http://dx.doi.org/10.1371/journal.pone.0276995 |