To Modify or Not to Modify: Allele‐Specific Effects of 3'UTR‐KCNQ1 Single Nucleotide Polymorphisms on Clinical Phenotype in a Long QT 1 Founder Population Segregating a Dominant‐Negative Mutation

BACKGROUND: There are conflicting reports with regard to the allele‐specific gene suppression effects of single nucleotide polymorphisms (SNPs) in the 3'untranslated region (3'UTR) of the KCNQ1 gene in long QT syndrome type 1 (LQT1) populations. Here we assess the allele‐specific effects o...

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Detalles Bibliográficos
Autores principales: Winbo, Annika, Diamant, Ulla‐Britt, Persson, Johan, Jensen, Steen M., Rydberg, Annika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683681/
https://www.ncbi.nlm.nih.gov/pubmed/36102229
http://dx.doi.org/10.1161/JAHA.122.025981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683681/
https://www.ncbi.nlm.nih.gov/pubmed/36102229
http://dx.doi.org/10.1161/JAHA.122.025981

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