Multicatalysis protocol enables direct and versatile enantioselective reductive transformations of secondary amides

The catalytic asymmetric geminal bis-nucleophilic addition to nonreactive functional groups is a type of highly desirable yet challenging transformation in organic chemistry. Here, we report the first catalytic asymmetric reductive/deoxygenative alkynylation of secondary amides. The method is based...

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Detalles Bibliográficos
Autores principales: Chen, Hang, Wu, Zhi-Zhong, Shao, Dong-Yang, Huang, Pei-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683713/
https://www.ncbi.nlm.nih.gov/pubmed/36417504
http://dx.doi.org/10.1126/sciadv.ade3431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683713/
https://www.ncbi.nlm.nih.gov/pubmed/36417504
http://dx.doi.org/10.1126/sciadv.ade3431

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