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Multicatalysis protocol enables direct and versatile enantioselective reductive transformations of secondary amides
The catalytic asymmetric geminal bis-nucleophilic addition to nonreactive functional groups is a type of highly desirable yet challenging transformation in organic chemistry. Here, we report the first catalytic asymmetric reductive/deoxygenative alkynylation of secondary amides. The method is based...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683713/ https://www.ncbi.nlm.nih.gov/pubmed/36417504 http://dx.doi.org/10.1126/sciadv.ade3431 |