Top2a promotes the development of social behavior via PRC2 and H3K27me3

Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhibition caused defects in social interaction and communication,...

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Detalles Bibliográficos
Autores principales: Geng, Yijie, Zhang, Tejia, Alonzo, Ivy G., Godar, Sean C., Yates, Christopher, Pluimer, Brock R., Harrison, Devin L., Nath, Anjali K., Yeh, Jing-Ruey Joanna, Drummond, Iain A., Bortolato, Marco, Peterson, Randall T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683714/
https://www.ncbi.nlm.nih.gov/pubmed/36417527
http://dx.doi.org/10.1126/sciadv.abm7069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683714/
https://www.ncbi.nlm.nih.gov/pubmed/36417527
http://dx.doi.org/10.1126/sciadv.abm7069

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