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Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects
Aberrations in tissue-specific enhancers underlie many developmental defects. Disrupting a noncoding region distal from the human SOX9 gene causes the Pierre Robin sequence (PRS) characterized by the undersized lower jaw. Such a craniofacial-specific defect has been previously linked to enhancers tr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683718/ https://www.ncbi.nlm.nih.gov/pubmed/36417512 http://dx.doi.org/10.1126/sciadv.abo3648 |