TDP-43 safeguards the embryo genome from L1 retrotransposition

Transposable elements (TEs) are genomic parasites that propagate within the host genome and introduce mutations. Long interspersed nuclear element-1 (LINE-1 or L1) is the major TE class, which occupies nearly 20% of the mouse genome. L1 is highly active in mammalian preimplantation embryos, posing a...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ten D., Murano, Kensaku, Kitano, Tomohiro, Guo, Youjia, Negishi, Lumi, Siomi, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683724/
https://www.ncbi.nlm.nih.gov/pubmed/36417507
http://dx.doi.org/10.1126/sciadv.abq3806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683724/
https://www.ncbi.nlm.nih.gov/pubmed/36417507
http://dx.doi.org/10.1126/sciadv.abq3806

Ejemplares similares