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TDP-43 safeguards the embryo genome from L1 retrotransposition

Transposable elements (TEs) are genomic parasites that propagate within the host genome and introduce mutations. Long interspersed nuclear element-1 (LINE-1 or L1) is the major TE class, which occupies nearly 20% of the mouse genome. L1 is highly active in mammalian preimplantation embryos, posing a...

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Detalles Bibliográficos
Autores principales:	Li, Ten D., Murano, Kensaku, Kitano, Tomohiro, Guo, Youjia, Negishi, Lumi, Siomi, Haruhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683724/ https://www.ncbi.nlm.nih.gov/pubmed/36417507 http://dx.doi.org/10.1126/sciadv.abq3806

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