Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning

Increasing the expression level of the SARS-CoV-2 spike (S) protein has been critical for COVID-19 vaccine development. While previous efforts largely focused on engineering the receptor-binding domain (RBD) and the S2 subunit, the amino-terminal domain (NTD) has been long overlooked because of the...

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Detalles Bibliográficos
Autores principales: Ouyang, Wenhao O., Tan, Timothy J.C., Lei, Ruipeng, Song, Ge, Kieffer, Collin, Andrabi, Raiees, Matreyek, Kenneth A., Wu, Nicholas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683733/
https://www.ncbi.nlm.nih.gov/pubmed/36417523
http://dx.doi.org/10.1126/sciadv.add7221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683733/
https://www.ncbi.nlm.nih.gov/pubmed/36417523
http://dx.doi.org/10.1126/sciadv.add7221

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