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Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning

Increasing the expression level of the SARS-CoV-2 spike (S) protein has been critical for COVID-19 vaccine development. While previous efforts largely focused on engineering the receptor-binding domain (RBD) and the S2 subunit, the amino-terminal domain (NTD) has been long overlooked because of the...

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Detalles Bibliográficos
Autores principales:	Ouyang, Wenhao O., Tan, Timothy J.C., Lei, Ruipeng, Song, Ge, Kieffer, Collin, Andrabi, Raiees, Matreyek, Kenneth A., Wu, Nicholas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683733/ https://www.ncbi.nlm.nih.gov/pubmed/36417523 http://dx.doi.org/10.1126/sciadv.add7221

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