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Structural and thermodynamic analyses of the β-to-α transformation in RfaH reveal principles of fold-switching proteins

The two-domain protein RfaH, a paralog of the universally conserved NusG/Spt5 transcription factors, is regulated by autoinhibition coupled to the reversible conformational switch of its 60-residue C-terminal Kyrpides, Ouzounis, Woese (KOW) domain between an α-hairpin and a β-barrel. In contrast, Nu...

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Detalles Bibliográficos
Autores principales: Zuber, Philipp K, Daviter, Tina, Heißmann, Ramona, Persau, Ulrike, Schweimer, Kristian, Knauer, Stefan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683785/
https://www.ncbi.nlm.nih.gov/pubmed/36255050
http://dx.doi.org/10.7554/eLife.76630