Cargando…

Structural and functional insights of the human peroxisomal ABC transporter ALDP

Adrenoleukodystrophy protein (ALDP) is responsible for the transport of very-long-chain fatty acids (VLCFAs) and corresponding CoA-esters across the peroxisomal membrane. Dysfunction of ALDP leads to peroxisomal metabolic disorder exemplified by X-linked adrenoleukodystrophy (ALD). Hundreds of ALD-c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Yutian, Zhang, Yanming, Wang, Wenhao, Lei, Jianlin, Ying, Zhengxin, Yang, Guanghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683791/ https://www.ncbi.nlm.nih.gov/pubmed/36374178 http://dx.doi.org/10.7554/eLife.75039

Ejemplares similares

Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP
por: Xiong, Chao, et al.
Publicado: (2023)

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation
por: Kolich, Ljuvica R, et al.
Publicado: (2020)

Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses
por: Wang, Ling, et al.
Publicado: (2020)

Exploring conformational equilibria of a heterodimeric ABC transporter
por: Timachi, M Hadi, et al.
Publicado: (2017)

Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump
por: Xu, Xin, et al.
Publicado: (2020)

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
por: Simon, Márton A, et al.
Publicado: (2023)

Ternary structure of the outer membrane transporter FoxA with resolved signalling domain provides insights into TonB-mediated siderophore uptake
por: Josts, Inokentijs, et al.
Publicado: (2019)

Structural insights into the activation of human calcium-sensing receptor
por: Chen, Xiaochen, et al.
Publicado: (2021)

Structural basis for mammalian nucleotide sugar transport
por: Ahuja, Shivani, et al.
Publicado: (2019)

Structural insight into the stabilization of microtubules by taxanes
por: Prota, Andrea E, et al.
Publicado: (2023)

Structural basis for the reaction cycle of DASS dicarboxylate transporters
por: Sauer, David B, et al.
Publicado: (2020)

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound
por: Coudray, Nicolas, et al.
Publicado: (2020)

Structural basis of substrate recognition by a polypeptide processing and secretion transporter
por: Kieuvongngam, Virapat, et al.
Publicado: (2020)

Structural and functional properties of a plant NRAMP-related aluminum transporter
por: Ramanadane, Karthik, et al.
Publicado: (2023)

Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates
por: Kermani, Ali A, et al.
Publicado: (2022)

Structural and mechanistic insights into the MCM8/9 helicase complex
por: Weng, Zhuangfeng, et al.
Publicado: (2023)

Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family
por: Ramanadane, Karthik, et al.
Publicado: (2022)

Structural insights into SETD3-mediated histidine methylation on β-actin
por: Guo, Qiong, et al.
Publicado: (2019)

Mechanism of substrate binding and transport in BASS transporters
por: Becker, Patrick, et al.
Publicado: (2023)

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1
por: Sun, Demeng, et al.
Publicado: (2020)

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
por: Verdon, Grégory, et al.
Publicado: (2014)

Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase
por: Falzone, Maria E, et al.
Publicado: (2019)

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
por: Zhao, Fenghui, et al.
Publicado: (2021)

Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange
por: Tippett, David N, et al.
Publicado: (2023)

Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex
por: Schuller, Sandra K, et al.
Publicado: (2020)

Binding and transport of D-aspartate by the glutamate transporter homolog Glt(Tk)
por: Arkhipova, Valentina, et al.
Publicado: (2019)

High-resolution structures with bound Mn(2+) and Cd(2+) map the metal import pathway in an Nramp transporter
por: Ray, Shamayeeta, et al.
Publicado: (2023)

Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport
por: Walter, Justin D, et al.
Publicado: (2019)

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
por: Yu, Xiaodi, et al.
Publicado: (2019)

Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15
por: Mahbub, Luba, et al.
Publicado: (2023)

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain
por: Zuo, Zhicheng, et al.
Publicado: (2019)

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism
por: Pospich, Sabrina, et al.
Publicado: (2021)

Structure of the transporter associated with antigen processing trapped by herpes simplex virus
por: Oldham, Michael L, et al.
Publicado: (2016)

A mechanism of uncompetitive inhibition of the serotonin transporter
por: Bhat, Shreyas, et al.
Publicado: (2023)

Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications
por: Noridomi, Kaori, et al.
Publicado: (2017)

Multiple kinesins induce tension for smooth cargo transport
por: Tjioe, Marco, et al.
Publicado: (2019)

Conserved allosteric inhibition mechanism in SLC1 transporters
por: Dong, Yang, et al.
Publicado: (2023)

A facile approach for the in vitro assembly of multimeric membrane transport proteins
por: Riederer, Erika A, et al.
Publicado: (2018)

Screening of candidate substrates and coupling ions of transporters by thermostability shift assays
por: Majd, Homa, et al.
Publicado: (2018)

Large-scale state-dependent membrane remodeling by a transporter protein
por: Zhou, Wenchang, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_iamnc3m4t91kb1ma2ofaufkq5k