Intelectin-1 binds and alters the localization of the mucus barrier–modifying bacterium Akkermansia muciniphila

Intelectin-1 (ITLN1) is a lectin secreted by intestinal epithelial cells (IECs) and upregulated in human ulcerative colitis (UC). We investigated how ITLN1 production is regulated in IECs and the biological effects of ITLN1 at the host–microbiota interface using mouse models. Our data show that ITLN...

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Detalles Bibliográficos
Autores principales: Matute, Juan D., Duan, Jinzhi, Flak, Magdalena B., Griebel, Paul, Tascon-Arcila, Jose A., Doms, Shauni, Hanley, Thomas, Antanaviciute, Agne, Gundrum, Jennifer, Mark Welch, Jessica L., Sit, Brandon, Abtahi, Shabnam, Fuhler, Gwenny M., Grootjans, Joep, Tran, Florian, Stengel, Stephanie T., White, James R., Krupka, Niklas, Haller, Dirk, Clare, Simon, Lawley, Trevor D., Kaser, Arthur, Simmons, Alison, Glickman, Jonathan N., Bry, Lynn, Rosenstiel, Philip, Borisy, Gary, Waldor, Matthew K., Baines, John F., Turner, Jerrold R., Blumberg, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683900/
https://www.ncbi.nlm.nih.gov/pubmed/36413219
http://dx.doi.org/10.1084/jem.20211938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683900/
https://www.ncbi.nlm.nih.gov/pubmed/36413219
http://dx.doi.org/10.1084/jem.20211938

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