Cargando…

Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach

INTRODUCTION: Rheumatoid arthritis (RA) has been associated with changes in lipid, arginine and NO metabolism with increased cardiovascular (CV) risk. The aim of this study is to evaluate the effect of tofacitinib, a Janus kinase (JAK) inhibitor, on arginine and methionine metabolism in correlation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soós, Boglárka, Hamar, Attila, Pusztai, Anita, Czókolyová, Monika, Végh, Edit, Szamosi, Szilvia, Pethő, Zsófia, Gulyás, Katalin, Kerekes, György, Szántó, Sándor, Szűcs, Gabriella, Christians, Uwe, Klawitter, Jelena, Seres, Tamás, Szekanecz, Zoltán
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684209/ https://www.ncbi.nlm.nih.gov/pubmed/36438060 http://dx.doi.org/10.3389/fmed.2022.1011734

Ejemplares similares

Prospective, simultaneous assessment of joint and vascular inflammation by PET/CT in tofacitinib-treated patients with rheumatoid arthritis: associations with vascular and bone status
por: Hamar, Attila, et al.
Publicado: (2021)

Effects of 1-year tofacitinib therapy on angiogenic biomarkers in rheumatoid arthritis
por: Kerekes, György, et al.
Publicado: (2023)

Effect of tofacitinib therapy on angiotensin converting enzyme activity in rheumatoid arthritis
por: Kacsándi, Dorottya, et al.
Publicado: (2023)

Effects of One-Year Tofacitinib Therapy on Lipids and Adipokines in Association with Vascular Pathophysiology in Rheumatoid Arthritis
por: Czókolyová, Monika, et al.
Publicado: (2022)

Angiotensin Converting Enzyme Activity in Anti-TNF-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients
por: Soós, Boglárka, et al.
Publicado: (2022)

Effects of one-year tofacitinib therapy on bone metabolism in rheumatoid arthritis
por: Hamar, A., et al.
Publicado: (2021)

Changes of Metabolic Biomarker Levels upon One-Year Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis: Associations with Vascular Pathophysiology
por: Czókolyová, Monika, et al.
Publicado: (2021)

Complex assessment of bone mineral density, fracture risk, vitamin D status, and bone metabolism in Hungarian systemic sclerosis patients
por: Horváth, Ágnes, et al.
Publicado: (2019)

Associations of vascular and bone status in arthritis patients
por: Pusztai, Anita, et al.
Publicado: (2021)

Peripheral quantitative computed tomography in the assessment of bone mineral density in anti-TNF-treated rheumatoid arthritis and ankylosing spondylitis patients
por: Juhász, Balázs, et al.
Publicado: (2021)

Gene expression analysis of vascular pathophysiology related to anti-TNF treatment in rheumatoid arthritis
por: Póliska, Szilárd, et al.
Publicado: (2019)

Rosuvastatin improves impaired endothelial function, lowers high sensitivity CRP, complement and immuncomplex production in patients with systemic sclerosis - a prospective case-series study
por: Timár, Orsolya, et al.
Publicado: (2013)

Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease
por: Tar, Ildikó, et al.
Publicado: (2021)

Effect of Fcγ-receptor 3a (FCGR3A) gene polymorphisms on rituximab therapy in Hungarian patients with rheumatoid arthritis
por: Pál, Ildikó, et al.
Publicado: (2017)

Effectiveness and waning of protection with the BNT162b2 vaccine against the SARS-CoV-2 Delta variant in immunocompromised individuals
por: Szekanecz, Zoltán, et al.
Publicado: (2023)

Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study
por: Pethő, Zsófia, et al.
Publicado: (2021)

Assessing the risk of rapid radiographic progression in Hungarian rheumatoid arthritis patients
por: Végh, Edit, et al.
Publicado: (2021)

Common mechanisms and holistic care in atherosclerosis and osteoporosis
por: Szekanecz, Zoltán, et al.
Publicado: (2019)

An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis
por: Szalai, Eszter, et al.
Publicado: (2021)

Effects of lovastatin on breast cancer cells: a proteo-metabonomic study
por: Klawitter, Jelena, et al.
Publicado: (2010)

A relative L‐arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition
por: Klawitter, Jelena, et al.
Publicado: (2017)

Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney
por: Klawitter, Jelena, et al.
Publicado: (2017)

Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice
por: Szántó, Sándor, et al.
Publicado: (2007)

Dynamic classification using case-specific training cohorts outperforms static gene expression signatures in breast cancer
por: Győrffy, Balázs, et al.
Publicado: (2015)

Tofacitinib
Publicado: (2012)

Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis
por: Oláh, Csaba, et al.
Publicado: (2017)

Determinants of biological drug survival in rheumatoid arthritis: evidence from a Hungarian rheumatology center over 8 years of retrospective data
por: Brodszky, Valentin, et al.
Publicado: (2017)

Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns
por: Shokati, Touraj, et al.
Publicado: (2023)

Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins
por: Bencsik, Norbert, et al.
Publicado: (2019)

Erratum to Tofacitinib
Publicado: (2012)

Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study
por: Klawitter, J, et al.
Publicado: (2009)

Mycophenolate Mofetil Enhances the Negative Effects of Sirolimus and Tacrolimus on Rat Kidney Cell Metabolism
por: Klawitter, Jelena, et al.
Publicado: (2014)

The Potential Diagnostic and Predictive Role of HbA1c in Diabetic, Septic Patients: A Retrospective Single-Center Study
por: Juhász, Imre, et al.
Publicado: (2022)

Personality and Suicidal Behavior in Old Age: A Systematic Literature Review
por: Szücs, Anna, et al.
Publicado: (2018)

Familial and social transmission of suicidal behavior in older adults
por: Kenneally, Laura B., et al.
Publicado: (2018)

Biomarkers to predict risk of venous thromboembolism in patients with rheumatoid arthritis receiving tofacitinib or tumour necrosis factor inhibitors
por: Weitz, Jeffrey I, et al.
Publicado: (2022)

Bioequivalence of the pharmacokinetics between tofacitinib aspartate and tofacitinib citrate in healthy subjects
por: Shin, Wonsuk, et al.
Publicado: (2020)

Tofacitinib reduces mortality in coronavirus disease 2019 Tofacitinib in COVID-19
por: Maslennikov, Roman, et al.
Publicado: (2021)

Tofacitinib is not a biologic
por: Marren, Amy S.
Publicado: (2017)

Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration
por: Berkó, Szilvia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_b4e330vj9jt6ecfi5rp0qb3k21