CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor

Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand. We have recently shown that overexpression of PC protein was assoc...

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Detalles Bibliográficos
Autores principales: Ngamkham, Jarunya, Siritutsoontorn, Siraprapa, Saisomboon, Saowaluk, Vaeteewoottacharn, Kulthida, Jitrapakdee, Sarawut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684343/
https://www.ncbi.nlm.nih.gov/pubmed/36439442
http://dx.doi.org/10.3389/fonc.2022.966089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684343/
https://www.ncbi.nlm.nih.gov/pubmed/36439442
http://dx.doi.org/10.3389/fonc.2022.966089

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