Cargando…

CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor

Pyruvate carboxylase (PC) is an important anaplerotic enzyme that replenishes the tricarboxylic acid cycle (TCA) intermediates. It prevents the collapse of the TCA cycle upon its intermediates are removed during high anabolic demand. We have recently shown that overexpression of PC protein was assoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ngamkham, Jarunya, Siritutsoontorn, Siraprapa, Saisomboon, Saowaluk, Vaeteewoottacharn, Kulthida, Jitrapakdee, Sarawut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684343/ https://www.ncbi.nlm.nih.gov/pubmed/36439442 http://dx.doi.org/10.3389/fonc.2022.966089

Ejemplares similares

Mechanisms of Inhibition of Rhizobium etli Pyruvate Carboxylase by l-Aspartate
por: Sirithanakorn, Chaiyos, et al.
Publicado: (2014)

Characterization of the Distal Promoter of the Human Pyruvate Carboxylase Gene in Pancreatic Beta Cells
por: Thonpho, Ansaya, et al.
Publicado: (2013)

Coordinating Role of His216 in MgATP Binding and Cleavage in Pyruvate Carboxylase
por: Adina-Zada, Abdussalam, et al.
Publicado: (2014)

Antitumor effects of flavopiridol, a cyclin-dependent kinase inhibitor, on human cholangiocarcinoma in vitro and in an in vivo xenograft model
por: Saisomboon, Saowaluk, et al.
Publicado: (2019)

Multiple E-Boxes in the Distal Promoter of the Rat Pyruvate Carboxylase Gene Function as a Glucose-Responsive Element
por: Wutthisathapornchai, Apilak, et al.
Publicado: (2014)

Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells
por: Phannasil, Phatchariya, et al.
Publicado: (2015)

Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
por: Rattanapornsompong, Khanti, et al.
Publicado: (2021)

Homophilic Interaction of CD147 Promotes IL-6-Mediated Cholangiocarcinoma Invasion via the NF-κB-Dependent Pathway
por: Dana, Paweena, et al.
Publicado: (2021)

Pyruvate carboxylase and cancer progression
por: Kiesel, Violet A., et al.
Publicado: (2021)

A Unique Case of Pyruvate Carboxylase Deficiency
por: Hidalgo, Jessica, et al.
Publicado: (2021)

HPV16 Oncoproteins Promote Cervical Cancer Invasiveness by Upregulating Specific Matrix Metalloproteinases
por: Kaewprag, Jittranan, et al.
Publicado: (2013)

Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5‐fluorouracil resistance in gastric cancer
por: Tan, Jia‐nan, et al.
Publicado: (2022)

Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis
por: Habarou, F., et al.
Publicado: (2014)

A distinct holoenzyme organization for two-subunit pyruvate carboxylase
por: Choi, Philip H., et al.
Publicado: (2016)

Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
por: Liu, Yumeng, et al.
Publicado: (2018)

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer
por: Shinde, Aparna, et al.
Publicado: (2018)

Fibroblast pyruvate carboxylase is required for collagen production in the tumor microenvironment
por: Schwörer, Simon, et al.
Publicado: (2021)

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1
por: Schoonjans, Céline A., et al.
Publicado: (2020)

The phenotype of a Plasmodium falciparum phosphoeno/pyruvate carboxylase null mutant
por: Storm, Janet, et al.
Publicado: (2010)

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
por: Kumashiro, Naoki, et al.
Publicado: (2013)

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
por: López-Alonso, Jorge Pedro, et al.
Publicado: (2022)

Immunodetection of Pyruvate Carboxylase Expression in Human Astrocytomas, Glioblastomas, Oligodendrogliomas, and Meningiomas
por: Gondáš, Eduard, et al.
Publicado: (2023)

Synergism between 5-fluorouracil and N-methylformamide in HT29 human colon cancer line.
por: Laudonio, N., et al.
Publicado: (1990)

Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment
por: MILCZAREK, MAGDALENA, et al.
Publicado: (2014)

Methoxyamine Enhances 5-Fluorouracil-Induced Radiosensitization in Colon Cancer Cell Line HT29
por: Khoei, Samideh, et al.
Publicado: (2017)

Expression of Pyruvate Carboxylase mRNA Variants in Liver of Dairy Cattle at Calving
por: Agca, Cansu, et al.
Publicado: (2007)

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
por: Lin, Qingxiang, et al.
Publicado: (2020)

Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis
por: Shen, Jun, et al.
Publicado: (2021)

Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis
por: Liu, Chang, et al.
Publicado: (2021)

Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet
por: Selen, Ebru S., et al.
Publicado: (2022)

Co-localization of Carbonic Anhydrase and Phosphoenol-pyruvate Carboxylase and Localization of Pyruvate Kinase in Roots and Hypocotyls of Etiolated Glycine max Seedlings
por: Dimou, Maria, et al.
Publicado: (2009)

Hepatic pyruvate carboxylase expression differed prior to hyperketonemia onset in transition dairy cows
por: Weld, Kristina A., et al.
Publicado: (2020)

Case report of Takotsubo syndrome following seizures in a patient with pyruvate carboxylase deficiency
por: Sahdev, Nikhil, et al.
Publicado: (2021)

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase
por: Kerr, Alastair G., et al.
Publicado: (2022)

Author Correction: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase
por: López-Alonso, Jorge Pedro, et al.
Publicado: (2022)

Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake
por: Liu, Yang, et al.
Publicado: (2022)

Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer
por: Kitayama, Kishu, et al.
Publicado: (2017)

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
por: Singleton, Dean C., et al.
Publicado: (2020)

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase
por: Izquierdo-Garcia, Jose L., et al.
Publicado: (2014)

Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells
por: Reed, Michelle A. C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fm40lco5ssi9agd8c765opkkj4