CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae

CRISPR-Cas mediated genome engineering has revolutionized functional genomics. However, understanding of DNA repair following Cas-mediated DNA cleavage remains incomplete. Using Cas12a ribonucleoprotein genome editing in the fungal pathogen, Magnaporthe oryzae, we detail non-canonical DNA repair out...

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Detalles Bibliográficos
Autores principales: Huang, Jun, Rowe, David, Subedi, Pratima, Zhang, Wei, Suelter, Tyler, Valent, Barbara, Cook, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684475/
https://www.ncbi.nlm.nih.gov/pubmed/36418866
http://dx.doi.org/10.1038/s41467-022-34736-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684475/
https://www.ncbi.nlm.nih.gov/pubmed/36418866
http://dx.doi.org/10.1038/s41467-022-34736-1

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