Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are associated with Alzheimer’s disease (AD). Here we show that the...

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Detalles Bibliográficos
Autores principales: Lordén, Gema, Wozniak, Jacob M., Doré, Kim, Dozier, Lara E., Cates-Gatto, Chelsea, Patrick, Gentry N., Gonzalez, David J., Roberts, Amanda J., Tanzi, Rudolph E., Newton, Alexandra C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684486/
https://www.ncbi.nlm.nih.gov/pubmed/36418293
http://dx.doi.org/10.1038/s41467-022-34679-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684486/
https://www.ncbi.nlm.nih.gov/pubmed/36418293
http://dx.doi.org/10.1038/s41467-022-34679-7

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