Sampling of structure and sequence space of small protein folds

Nature only samples a small fraction of the sequence space that can fold into stable proteins. Furthermore, small structural variations in a single fold, sometimes only a few amino acids, can define a protein’s molecular function. Hence, to design proteins with novel functionalities, such as molecul...

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Detalles Bibliográficos
Autores principales: Linsky, Thomas W., Noble, Kyle, Tobin, Autumn R., Crow, Rachel, Carter, Lauren, Urbauer, Jeffrey L., Baker, David, Strauch, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684540/
https://www.ncbi.nlm.nih.gov/pubmed/36418330
http://dx.doi.org/10.1038/s41467-022-34937-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684540/
https://www.ncbi.nlm.nih.gov/pubmed/36418330
http://dx.doi.org/10.1038/s41467-022-34937-8

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