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Sampling of structure and sequence space of small protein folds
Nature only samples a small fraction of the sequence space that can fold into stable proteins. Furthermore, small structural variations in a single fold, sometimes only a few amino acids, can define a protein’s molecular function. Hence, to design proteins with novel functionalities, such as molecul...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684540/ https://www.ncbi.nlm.nih.gov/pubmed/36418330 http://dx.doi.org/10.1038/s41467-022-34937-8 |