Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

In the widely used Carbon tetrachloride (CCl(4))-induced acute liver injury (ALI) mouse model, hepatocytes are known to die from programmed cell death (PCD) processes including apoptosis and necroptosis. Both in vivo and in vitro experiments showed that CCl(4) treatment could induce both apoptosis a...

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Detalles Bibliográficos
Autores principales: Lu, Ke, Shen, Si-Yu, Luo, Ou-Yang, Lu, Yue, Shi, Tian-Shu, Wu, Jing, Cheng, Qi, Teng, Hua-Jian, Chen, Di, Lu, Xiang, Li, Chao-Jun, Jiang, Qing, Fang, Lei, Xue, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684557/
https://www.ncbi.nlm.nih.gov/pubmed/36418313
http://dx.doi.org/10.1038/s41419-022-05353-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684557/
https://www.ncbi.nlm.nih.gov/pubmed/36418313
http://dx.doi.org/10.1038/s41419-022-05353-z

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