Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice

Huntington disease (HD) is caused by the expansion of CAG triplet repeats in exon 1 of the huntingtin (HTT) gene, which also encodes the first 17 amino acids (N-17) that can modulate the toxicity of the expanded polyQ repeat. N-17 are conserved in a wide range of species and are found to influence t...

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Detalles Bibliográficos
Autores principales: Zhao, Xianxian, Sun, Yize, Wang, Zhifu, Chen, Laiqiang, Li, Shihua, Li, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684630/
https://www.ncbi.nlm.nih.gov/pubmed/36439204
http://dx.doi.org/10.3389/fncel.2022.1021592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684630/
https://www.ncbi.nlm.nih.gov/pubmed/36439204
http://dx.doi.org/10.3389/fncel.2022.1021592

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