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Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice
Huntington disease (HD) is caused by the expansion of CAG triplet repeats in exon 1 of the huntingtin (HTT) gene, which also encodes the first 17 amino acids (N-17) that can modulate the toxicity of the expanded polyQ repeat. N-17 are conserved in a wide range of species and are found to influence t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684630/ https://www.ncbi.nlm.nih.gov/pubmed/36439204 http://dx.doi.org/10.3389/fncel.2022.1021592 |