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Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma

Dedifferentiated liposarcoma (DDLPS) is an aggressive adipogenic cancer with poor prognosis. DDLPS tumors are only modestly sensitive to chemotherapy and radiation, and there is a need for more effective therapies. Genetically, DDLPS is characterized by a low tumor mutational burden and frequent chr...

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Detalles Bibliográficos
Autores principales: Traweek, Raymond S., Cope, Brandon M., Roland, Christina L., Keung, Emily Z., Nassif, Elise F., Erstad, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684653/
https://www.ncbi.nlm.nih.gov/pubmed/36439412
http://dx.doi.org/10.3389/fonc.2022.1006959