Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response

BACKGROUND: CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular glycoprotein thrombospondin-1 (TSP1). We examined the impact of the CD47/TSP1 signaling axis on melanoma patient response to anti-PD-1 therapy due to alterations in T cell activat...

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Detalles Bibliográficos
Autores principales: Stirling, Elizabeth R, Terabe, Masaki, Wilson, Adam S, Kooshki, Mitra, Yamaleyeva, Liliya M, Alexander-Miller, Martha A, Zhang, Wei, Miller, Lance D, Triozzi, Pierre L, Soto-Pantoja, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685258/
https://www.ncbi.nlm.nih.gov/pubmed/36418073
http://dx.doi.org/10.1136/jitc-2022-004712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685258/
https://www.ncbi.nlm.nih.gov/pubmed/36418073
http://dx.doi.org/10.1136/jitc-2022-004712

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