Cargando…

Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium

Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle‐mediated RNA interference therapy aimed at enhancing its proliferative capacity, necessary for tissue regene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maurizi, Eleonora, Martella, Davide Alessandro, Schiroli, Davide, Merra, Alessia, Mustfa, Salman Ahmad, Pellegrini, Graziella, Macaluso, Claudio, Chiappini, Ciro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9685449/ https://www.ncbi.nlm.nih.gov/pubmed/36253148 http://dx.doi.org/10.1002/advs.202203257

Ejemplares similares

Fluctuations in Corneal Endothelial LAP2 Expression Levels Correlate with Passage Dependent Declines in Their Cell Proliferative Activity
por: Maurizi, Eleonora, et al.
Publicado: (2022)

CRISPR/Cas-Assisted Nanoneedle Sensor for Adenosine Triphosphate Detection in Living Cells
por: Kim, Hongki, et al.
Publicado: (2023)

A fine-tuned β-catenin regulation during proliferation of corneal endothelial cells revealed using proteomics analysis
por: Maurizi, Eleonora, et al.
Publicado: (2020)

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide
por: Schiroli, Davide, et al.
Publicado: (2019)

Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads
por: Gopal, Sahana, et al.
Publicado: (2019)

Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery
por: Hansel, Catherine S., et al.
Publicado: (2019)

Regenerative Medicine of Epithelia: Lessons From the Past and Future Goals
por: Maurizi, Eleonora, et al.
Publicado: (2021)

Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
por: Chiappini, Ciro, et al.
Publicado: (2015)

Surgery Versus ATMPs: An Example From Ophthalmology
por: Magrelli, Federica M., et al.
Publicado: (2020)

Potential Effects of Corneal Cross-Linking upon the Limbus
por: Moore, Johnny E., et al.
Publicado: (2016)

Therapeutic siRNA silencing in inflammatory monocytes
por: Leuschner, Florian, et al.
Publicado: (2011)

From Zirconium Nanograins to Zirconia Nanoneedles
por: Zalnezhad, E., et al.
Publicado: (2016)

Nanocarriers for delivery of siRNA as gene silencing mediator
por: Morales-Becerril, Aideé, et al.
Publicado: (2022)

Tissue Engineering of Corneal Endothelium
por: Mimura, Tatsuya, et al.
Publicado: (2012)

Photoluminescence enhancement of quantum dots on Ag nanoneedles
por: Ahmed, Syed Rahin, et al.
Publicado: (2012)

Optical Response of Silver Nanoneedles on a Mirror
por: Keeman, Arjan, et al.
Publicado: (2015)

Biodegradable silicon nanoneedles for ocular drug delivery
por: Park, Woohyun, et al.
Publicado: (2022)

In vivo silencing of alpha-synuclein using naked siRNA
por: Lewis, Jada, et al.
Publicado: (2008)

High potency silencing by single-stranded boranophosphate siRNA
por: Hall, Allison H. S., et al.
Publicado: (2006)

Primary and Secondary siRNAs in Geminivirus-induced Gene Silencing
por: Aregger, Michael, et al.
Publicado: (2012)

Chitosan Hydrogel as siRNA vector for prolonged gene silencing
por: Ma, Zhiwei, et al.
Publicado: (2014)

siRNA Versus miRNA as Therapeutics for Gene Silencing
por: Lam, Jenny K W, et al.
Publicado: (2015)

Strategies for Improving siRNA-Induced Gene Silencing Efficiency
por: Safari, Fatemeh, et al.
Publicado: (2017)

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing
por: Vollmann, Elisabeth H., et al.
Publicado: (2017)

Porcine Organotypic Epicardial Slice Protocol: A Tool for the Study of Epicardium in Cardiovascular Research
por: Maselli, Davide, et al.
Publicado: (2022)

Nanoneedles of Mixed Transition Metal Phosphides as Bifunctional Catalysts for Electrocatalytic Water Splitting in Alkaline Media
por: Salvò, Davide, et al.
Publicado: (2023)

Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice
por: Hattori, Yoshiyuki, et al.
Publicado: (2020)

Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo
por: Chung, Jihwa, et al.
Publicado: (2016)

RORC2 Gene Silencing in Human Th17 Cells by siRNA: Design and Evaluation of Highly Efficient siRNA
por: Hakemi, Mazdak Ganjalikhani, et al.
Publicado: (2013)

GW body disassembly triggered by siRNAs independently of their silencing activity
por: Serman, A., et al.
Publicado: (2007)

The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci
por: Shin, Jun-Hye, et al.
Publicado: (2013)

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review
por: Wu, Jiangyu, et al.
Publicado: (2013)

Differences in silencing of mismatched targets by sliced versus diced siRNAs
por: Sun, Guihua, et al.
Publicado: (2018)

SiRNA silencing efficacy prediction based on a deep architecture
por: Han, Ye, et al.
Publicado: (2018)

Nuclear-targeted siRNA delivery for long-term gene silencing
por: Li, Na, et al.
Publicado: (2017)

siRNA Design to Silence the 3′UTR Region of Zika Virus
por: Perez-Mendez, María, et al.
Publicado: (2020)

Synthesis of Yttrium Oxide Nanoneedles with Carbon Dioxide Carbonization
por: Rao, Minglu, et al.
Publicado: (2022)

Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation
por: Ng, Bruce, et al.
Publicado: (2019)

Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
por: Shawan, Mohammad Mahfuz Ali Khan, et al.
Publicado: (2021)

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
por: Alshehri, Abdullah, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5199lvvuqn6ogtunbtqmt4cvvm