Cargando…
Peptide Carbocycles: From −SS– to −CC– via a Late-Stage “Snip-and-Stitch”
[Image: see text] One way to improve the therapeutic potential of peptides is through cyclization. This is commonly done using a disulfide bond between two cysteine residues in the peptide. However, disulfide bonds are susceptible to reductive cleavage, and this can deactivate the peptide and endang...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686213/ https://www.ncbi.nlm.nih.gov/pubmed/36439308 http://dx.doi.org/10.1021/acscentsci.2c00456 |