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Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort

BACKGROUND: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. METHODS: Assessment at baseline (three months or more following a...

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Autores principales: Schild, Ann-Katrin, Goereci, Yasemin, Scharfenberg, Daniel, Klein, Kim, Lülling, Joachim, Meiberth, Dix, Schweitzer, Finja, Stürmer, Sophie, Zeyen, Philip, Sahin, Derya, Fink, Gereon R., Jessen, Frank, Franke, Christiana, Onur, Oezguer A., Kessler, Josef, Warnke, Clemens, Maier, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686246/
https://www.ncbi.nlm.nih.gov/pubmed/36422669
http://dx.doi.org/10.1007/s00415-022-11444-w
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author Schild, Ann-Katrin
Goereci, Yasemin
Scharfenberg, Daniel
Klein, Kim
Lülling, Joachim
Meiberth, Dix
Schweitzer, Finja
Stürmer, Sophie
Zeyen, Philip
Sahin, Derya
Fink, Gereon R.
Jessen, Frank
Franke, Christiana
Onur, Oezguer A.
Kessler, Josef
Warnke, Clemens
Maier, Franziska
author_facet Schild, Ann-Katrin
Goereci, Yasemin
Scharfenberg, Daniel
Klein, Kim
Lülling, Joachim
Meiberth, Dix
Schweitzer, Finja
Stürmer, Sophie
Zeyen, Philip
Sahin, Derya
Fink, Gereon R.
Jessen, Frank
Franke, Christiana
Onur, Oezguer A.
Kessler, Josef
Warnke, Clemens
Maier, Franziska
author_sort Schild, Ann-Katrin
collection PubMed
description BACKGROUND: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. METHODS: Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered. RESULTS: Of the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue. CONCLUSION: Neurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11444-w.
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spelling pubmed-96862462022-11-28 Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort Schild, Ann-Katrin Goereci, Yasemin Scharfenberg, Daniel Klein, Kim Lülling, Joachim Meiberth, Dix Schweitzer, Finja Stürmer, Sophie Zeyen, Philip Sahin, Derya Fink, Gereon R. Jessen, Frank Franke, Christiana Onur, Oezguer A. Kessler, Josef Warnke, Clemens Maier, Franziska J Neurol Original Communication BACKGROUND: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. METHODS: Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered. RESULTS: Of the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue. CONCLUSION: Neurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11444-w. Springer Berlin Heidelberg 2022-11-23 2023 /pmc/articles/PMC9686246/ /pubmed/36422669 http://dx.doi.org/10.1007/s00415-022-11444-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Communication
Schild, Ann-Katrin
Goereci, Yasemin
Scharfenberg, Daniel
Klein, Kim
Lülling, Joachim
Meiberth, Dix
Schweitzer, Finja
Stürmer, Sophie
Zeyen, Philip
Sahin, Derya
Fink, Gereon R.
Jessen, Frank
Franke, Christiana
Onur, Oezguer A.
Kessler, Josef
Warnke, Clemens
Maier, Franziska
Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
title Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
title_full Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
title_fullStr Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
title_full_unstemmed Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
title_short Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
title_sort multidomain cognitive impairment in non-hospitalized patients with the post-covid-19 syndrome: results from a prospective monocentric cohort
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686246/
https://www.ncbi.nlm.nih.gov/pubmed/36422669
http://dx.doi.org/10.1007/s00415-022-11444-w
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