Cargando…

O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson’s Disease Mouse Models

O-cyclic phytosphingosine-1-phosphate (cPS1P) is a novel and chemically synthesized sphingosine metabolite derived from phytosphingosine-1-phosphate (S1P). This study was undertaken to unveil the potential neuroprotective effects of cPS1P on two different mouse models of Parkinson’s disease (PD). Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hyeon Jin, Choe, Kyonghwan, Park, Jun Sung, Khan, Amjad, Kim, Min Woo, Park, Tae Ju, Kim, Myeong Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686509/ https://www.ncbi.nlm.nih.gov/pubmed/36358479 http://dx.doi.org/10.3390/antiox11112107

Ejemplares similares

Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson’s Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment
por: Atiq, Abubakar, et al.
Publicado: (2023)

Pharmacological Inhibition of Spleen Tyrosine Kinase Suppressed Neuroinflammation and Cognitive Dysfunction in LPS-Induced Neurodegeneration Model
por: Kim, Min Woo, et al.
Publicado: (2022)

Corrigendum to “Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice”
por: Park, Youngheon, et al.
Publicado: (2023)

Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson’s Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways
por: Rehman, Inayat Ur, et al.
Publicado: (2022)

Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways
por: Park, Jun Sung, et al.
Publicado: (2023)

Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions
por: Ikram, Muhammad, et al.
Publicado: (2021)

O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice
por: Park, Youngheon, et al.
Publicado: (2023)

Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling
por: Jang, Ji-Hye, et al.
Publicado: (2021)

Revealing a signaling role of phytosphingosine-1-phosphate in yeast
por: Cowart, L Ashley, et al.
Publicado: (2010)

Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling
por: Rehman, Shafiq Ur, et al.
Publicado: (2019)

Systematic Review of the Common Pathophysiological Mechanisms in COVID-19 and Neurodegeneration: The Role of Bioactive Compounds and Natural Antioxidants
por: Choe, Kyonghwan, et al.
Publicado: (2022)

Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells
por: Han, Sang Hee, et al.
Publicado: (2015)

Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment
por: Khan, Amjad, et al.
Publicado: (2023)

Establishing Co-Culture Blood–Brain Barrier Models for Different Neurodegeneration Conditions to Understand Its Effect on BBB Integrity
por: Park, Jun Sung, et al.
Publicado: (2023)

Phytosphingosine induces systemic acquired resistance through activation of sphingosine kinase
por: Seo, So Yeon, et al.
Publicado: (2021)

A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer’s Disease
por: Park, Jun Sung, et al.
Publicado: (2023)

Antimicrobial effect of phytosphingosine in acrylic resin
por: Pejon, Luiza Sanchez, et al.
Publicado: (2023)

Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury
por: Alam, Sayed Ibrar, et al.
Publicado: (2021)

Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro
por: Khan, Amjad, et al.
Publicado: (2019)

Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury
por: Ahmad, Riaz, et al.
Publicado: (2022)

The effect of Phytosphingosine and bioactive glass-ceramics in preventing dental enamel erosion
por: de Araujo, Leticia Campos, et al.
Publicado: (2023)

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
por: Ahmad, Sareer, et al.
Publicado: (2021)

Calcineurin and glial signaling: neuroinflammation and beyond
por: Furman, Jennifer L, et al.
Publicado: (2014)

Novel phytoceramides containing fatty acids of diverse chain lengths are better than a single C18-ceramide N-stearoyl phytosphingosine to improve the physiological properties of human stratum corneum
por: Oh, Myoung Jin, et al.
Publicado: (2017)

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease
por: Quan, Wei, et al.
Publicado: (2023)

Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits
por: Carrascal, Livia, et al.
Publicado: (2022)

17β-Estradiol Abrogates Oxidative Stress and Neuroinflammation after Cortical Stab Wound Injury
por: Saeed, Kamran, et al.
Publicado: (2021)

Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson’s disease
por: Kwon, Kyum-Yil, et al.
Publicado: (2022)

Nicotinamide Ameliorates Amyloid Beta-Induced Oxidative Stress-Mediated Neuroinflammation and Neurodegeneration in Adult Mouse Brain
por: Rehman, Inayat Ur, et al.
Publicado: (2021)

Neuroinflammation and Glial Phenotypic Changes in Alpha-Synucleinopathies
por: Refolo, Violetta, et al.
Publicado: (2019)

Neuroinflammation and glial cell activation in mental disorders
por: Almeida, Priscila G.C., et al.
Publicado: (2019)

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease
por: Al-Ghraiybah, Nour F., et al.
Publicado: (2022)

Surgical Resection of Non-Glial Tumors in the Motor Cortex
por: Lee, Seong-Jong, et al.
Publicado: (2016)

Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells
por: Nakashima, Keiko, et al.
Publicado: (2022)

Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models
por: Nădăban, Andreea, et al.
Publicado: (2023)

Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration
por: Ikram, Muhammad, et al.
Publicado: (2021)

Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?
por: Iseki, Tatou, et al.
Publicado: (2023)

Neuroinflammation and Mitochondrial Dysfunction in Parkinson’s Disease: Connecting Neuroimaging with Pathophysiology
por: Pizarro-Galleguillos, Benjamin Matís, et al.
Publicado: (2023)

Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling
por: Ikram, Muhammad, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vk0csb8q6bfnqb65f3og8qnptq