Histidine 19 Residue Is Essential for Cell Internalization of Antifungal Peptide SmAP(α1-21) Derived from the α-Core of the Silybum marianum Defensin DefSm2-D in Fusarium graminearum

The synthetic peptide SmAP(α1-21) (KLCEKPSKTWFGNCGNPRHCG) derived from DefSm2-D defensin α-core is active at micromolar concentrations against the phytopathogenic fungus Fusarium graminearum and has a multistep mechanism of action that includes alteration of the fungal cell wall and membrane permeab...

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Detalles Bibliográficos
Autores principales: Fernández, Agustina, González, Mariano, Malbrán, Ismael, Vázquez, Romina F., Maté, Sabina M., Guzmán, Fanny, Bakás, Laura S., Vairo Cavalli, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686561/
https://www.ncbi.nlm.nih.gov/pubmed/36358156
http://dx.doi.org/10.3390/antibiotics11111501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686561/
https://www.ncbi.nlm.nih.gov/pubmed/36358156
http://dx.doi.org/10.3390/antibiotics11111501

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