Defining Exposure Predictors of Meropenem That Are Associated with Improved Survival for Severe Bacterial Infection: A Preclinical PK/PD Study in Sepsis Rat Model

Background: The pharmacokinetic/pharmacodynamic (PK/PD) index of carbapenems that best correlates with in vivo antimicrobial activity is percent time of dosing interval in which free drug concentration remains above MIC (%fT > MIC), while the magnitudes of the PK/PD index of carbapenems remains u...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Liu, Lanyu, Wu, Qiping, Yin, Qiufen, Xie, Feifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686672/
https://www.ncbi.nlm.nih.gov/pubmed/36421304
http://dx.doi.org/10.3390/antibiotics11111660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686672/
https://www.ncbi.nlm.nih.gov/pubmed/36421304
http://dx.doi.org/10.3390/antibiotics11111660

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