Cargando…

Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer

Some colorectal cancer (CRC) patients are resistant to 5-fluorouracil (5-FU), and high expression levels of thymidylate synthase (TS) contribute to this resistance. This study investigated whether quercetin, a representative polyphenol compound, could enhance the effect of 5-FU in CRC cells. Quercet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Changwon, Song, Jisoo, Park, Sunwoo, Ham, Jiyeon, Park, Wonhyoung, Park, Hahyun, An, Garam, Hong, Taeyeon, Kim, Hee Seung, Song, Gwonhwa, Lim, Whasun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686910/ https://www.ncbi.nlm.nih.gov/pubmed/36358529 http://dx.doi.org/10.3390/antiox11112158

Ejemplares similares

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells
por: Yang, Changwon, et al.
Publicado: (2021)

ER-Mitochondria Calcium Flux by β-Sitosterol Promotes Cell Death in Ovarian Cancer
por: Bae, Hyocheol, et al.
Publicado: (2021)

Brassinin Inhibits Proliferation in Human Liver Cancer Cells via Mitochondrial Dysfunction
por: Hong, Taeyeon, et al.
Publicado: (2021)

Fraxetin Suppresses Cell Proliferation and Induces Apoptosis through Mitochondria Dysfunction in Human Hepatocellular Carcinoma Cell Lines Huh7 and Hep3B
por: Song, Jisoo, et al.
Publicado: (2021)

Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress
por: Park, Wonhyoung, et al.
Publicado: (2019)

Alpinumisoflavone Activates Disruption of Calcium Homeostasis, Mitochondria and Autophagosome to Suppress Development of Endometriosis
por: Song, Jisoo, et al.
Publicado: (2023)

Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer
por: Hong, Taeyeon, et al.
Publicado: (2022)

Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function
por: Song, Jisoo, et al.
Publicado: (2022)

Antiproliferative Effect of 4-Methylumbelliferone in Epithelial Ovarian Cancer Cells Is Mediated by Disruption of Intracellular Homeostasis and Regulation of PI3K/AKT and MAPK Signaling
por: An, Garam, et al.
Publicado: (2020)

Polydatin Counteracts 5-Fluorouracil Resistance by Enhancing Apoptosis via Calcium Influx in Colon Cancer
por: Bae, Hyocheol, et al.
Publicado: (2021)

Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol
por: Bae, Hyocheol, et al.
Publicado: (2021)

tRNA(Lys)-Derived Fragment Alleviates Cisplatin-Induced Apoptosis in Prostate Cancer Cells
por: Yang, Changwon, et al.
Publicado: (2021)

Alpinumisoflavone Impairs Mitochondrial Respiration via Oxidative Stress and MAPK/PI3K Regulation in Hepatocellular Carcinoma Cells
por: Jang, Hyewon, et al.
Publicado: (2022)

Hesperidin Suppresses the Proliferation of Prostate Cancer Cells by Inducing Oxidative Stress and Disrupting Ca(2+) Homeostasis
por: Jeong, Seon Ae, et al.
Publicado: (2022)

Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer
por: Lee, Jin-Young, et al.
Publicado: (2020)

Eupatilin Impacts on the Progression of Colon Cancer by Mitochondria Dysfunction and Oxidative Stress
por: Lee, Minkyeong, et al.
Publicado: (2021)

Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model
por: Park, Soo Jin, et al.
Publicado: (2022)

Methiothepin Suppresses Human Ovarian Cancer Cell Growth by Repressing Mitochondrion-Mediated Metabolism and Inhibiting Angiogenesis In Vivo
por: Lee, Jin-Young, et al.
Publicado: (2020)

Inhibition of miR-214-3p Aids in Preventing Epithelial Ovarian Cancer Malignancy by Increasing the Expression of LHX6
por: Yang, Changwon, et al.
Publicado: (2019)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis
por: Bae, Hyocheol, et al.
Publicado: (2020)

Laminarin-Derived from Brown Algae Suppresses the Growth of Ovarian Cancer Cells via Mitochondrial Dysfunction and ER Stress
por: Bae, Hyocheol, et al.
Publicado: (2020)

3′-UTR Polymorphisms in Thymidylate Synthase with Colorectal Cancer Prevalence and Prognosis
por: Jeon, Young-Joo, et al.
Publicado: (2021)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Gentisyl Alcohol Inhibits Proliferation and Induces Apoptosis via Mitochondrial Dysfunction and Regulation of MAPK and PI3K/AKT Pathways in Epithelial Ovarian Cancer Cells
por: Ham, Jiyeon, et al.
Publicado: (2019)

Discovery of Prognostic Factors for Diagnosis and Treatment of Epithelial-Derived Ovarian Cancer from Laying Hens
por: Lim, Whasun, et al.
Publicado: (2013)

Identification of Novel Regulatory Genes in Development of the Avian Reproductive Tracts
por: Lim, Whasun, et al.
Publicado: (2014)

Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction
por: Lim, Whasun, et al.
Publicado: (2017)

Diagnostic and prognostic value of thymidylate synthase expression in breast cancer
por: Song, Shaoran, et al.
Publicado: (2020)

Clinical Phenotypes of Tumors Invading the Rectosigmoid Colon Affecting the Extent of Debulking Surgery and Survival in Advanced Ovarian Cancer
por: Park, Soo Jin, et al.
Publicado: (2021)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma
por: YOKOTA, KEISUKE, et al.
Publicado: (2012)

Analysis of mRNA recognition by human thymidylate synthase
por: Brunn, Nicholas D., et al.
Publicado: (2014)

Bacterial versus human thymidylate synthase: Kinetics and functionality
por: Islam, Zahidul, et al.
Publicado: (2018)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction
por: Bae, Hyocheol, et al.
Publicado: (2020)

Structural Analysis of Thymidylate Synthase from Kaposi’s Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed
por: Choi, Yong Mi, et al.
Publicado: (2016)

Interaction between Thymidylate Synthase and Its Cognate mRNA in Zebrafish Embryos
por: Zhang, Yuyan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7aubjjra3clksfjo0s2mqtobiq