Copper Depletion Strongly Enhances Ferroptosis via Mitochondrial Perturbation and Reduction in Antioxidative Mechanisms

Copper serves as a co-factor for a host of metalloenzymes, particularly cytochrome c oxidase (COX). Although it is known that impaired COX function can lead to the excessive accumulation of reactive oxygen species (ROS), the mechanisms underlying how copper depletion leads to cell damage are poorly...

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Detalles Bibliográficos
Autores principales: Li, Fan, Wu, Xiaojing, Liu, Hongli, Liu, Mengqi, Yue, Zhengkai, Wu, Zhenyu, Liu, Lei, Li, Fuchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687009/
https://www.ncbi.nlm.nih.gov/pubmed/36358457
http://dx.doi.org/10.3390/antiox11112084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687009/
https://www.ncbi.nlm.nih.gov/pubmed/36358457
http://dx.doi.org/10.3390/antiox11112084

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