Progression of the pluripotent epiblast depends upon the NMD factor UPF2

Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that degrades RNAs harboring in-frame stop codons in specific contexts. Loss of NMD factors leads to embryonic lethality in organisms spanning the phylogenetic scale, but the mechanism remains unknown. Here, we report that...

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Detalles Bibliográficos
Autores principales: Chousal, Jennifer N., Sohni, Abhishek, Vitting-Seerup, Kristoffer, Cho, Kyucheol, Kim, Matthew, Tan, Kun, Porse, Bo, Wilkinson, Miles F., Cook-Andersen, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687065/
https://www.ncbi.nlm.nih.gov/pubmed/36255229
http://dx.doi.org/10.1242/dev.200764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687065/
https://www.ncbi.nlm.nih.gov/pubmed/36255229
http://dx.doi.org/10.1242/dev.200764

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