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Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism

Cellular senescence is linked with chemotherapy resistance. Based on previous studies, GRP78 is a signal transducer in senescent cells. However, the association between GRP78 and stem cell phenotype remains unknown. Cisplatin treatment was clarified to induce cellular senescence leading to stemness...

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Detalles Bibliográficos
Autores principales: Sriratanasak, Nicharat, Chunhacha, Preedakorn, Ei, Zin Zin, Chanvorachote, Pithi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687146/
https://www.ncbi.nlm.nih.gov/pubmed/36359223
http://dx.doi.org/10.3390/biomedicines10112703

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