Gold-Based Metal Drugs as Inhibitors of Coronavirus Proteins: The Inhibition of SARS-CoV-2 Main Protease by Auranofin and Its Analogs

Gold compounds have a long tradition in medicine and offer many opportunities for new therapeutic applications. Herein, we evaluated the lead compound Auranofin and five related gold(I) complexes as possible inhibitors of SARS-CoV-2 Main Protease (SARS-CoV-2 M(pro)), a validated drug target for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Massai, Lara, Grifagni, Deborah, De Santis, Alessia, Geri, Andrea, Cantini, Francesca, Calderone, Vito, Banci, Lucia, Messori, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687241/
https://www.ncbi.nlm.nih.gov/pubmed/36421689
http://dx.doi.org/10.3390/biom12111675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687241/
https://www.ncbi.nlm.nih.gov/pubmed/36421689
http://dx.doi.org/10.3390/biom12111675

Ejemplares similares