Fine-Tuning of mTORC1-ULK1-PP2A Regulatory Triangle Is Crucial for Robust Autophagic Response upon Cellular Stress

Autophagy-dependent cellular survival is tightly regulated by both kinases and phosphatases. While mTORC1 inhibits autophagy by phosphorylating ULK1, PP2A is able to remove this phosphate group from ULK1 and promotes the key inducer of autophagosome formation. However, ULK1 inhibits mTORC1, mTORC1 i...

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Detalles Bibliográficos
Autores principales: Hajdú, Bence, Holczer, Marianna, Horváth, Gergely, Szederkényi, Gábor, Kapuy, Orsolya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687272/
https://www.ncbi.nlm.nih.gov/pubmed/36358936
http://dx.doi.org/10.3390/biom12111587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687272/
https://www.ncbi.nlm.nih.gov/pubmed/36358936
http://dx.doi.org/10.3390/biom12111587

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