Sequence Properties of an Intramolecular Interaction that Inhibits p53 DNA Binding

An intramolecular interaction between the p53 transactivation and DNA binding domains inhibits DNA binding. To study this autoinhibition, we used a fragment of p53, referred to as ND WT, containing the N-terminal transactivation domains (TAD1 and TAD2), a proline rich region (PRR), and the DNA bindi...

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Detalles Bibliográficos
Autores principales: Gregory, Emily, Daughdrill, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687289/
https://www.ncbi.nlm.nih.gov/pubmed/36358908
http://dx.doi.org/10.3390/biom12111558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687289/
https://www.ncbi.nlm.nih.gov/pubmed/36358908
http://dx.doi.org/10.3390/biom12111558

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