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Sequence Properties of an Intramolecular Interaction that Inhibits p53 DNA Binding
An intramolecular interaction between the p53 transactivation and DNA binding domains inhibits DNA binding. To study this autoinhibition, we used a fragment of p53, referred to as ND WT, containing the N-terminal transactivation domains (TAD1 and TAD2), a proline rich region (PRR), and the DNA bindi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687289/ https://www.ncbi.nlm.nih.gov/pubmed/36358908 http://dx.doi.org/10.3390/biom12111558 |