Individualization of Mycophenolic Acid Therapy through Pharmacogenetic, Pharmacokinetic and Pharmacodynamic Testing

Mycophenolic acid (MPA) is a widely used immunosuppressive agent and exerts its effect by inhibiting inosine 5′-monophosphate dehydrogenase (IMPDH), the main regulating enzyme of purine metabolism. However, significant unexplained differences in the efficacy and tolerability of MPA therapy pose a cl...

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Detalles Bibliográficos
Autores principales: Winnicki, Wolfgang, Fichtenbaum, Andreas, Mitulovič, Goran, Herkner, Harald, Regele, Florina, Baier, Michael, Zelzer, Sieglinde, Wagner, Ludwig, Sengoelge, Guerkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687418/
https://www.ncbi.nlm.nih.gov/pubmed/36359401
http://dx.doi.org/10.3390/biomedicines10112882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687418/
https://www.ncbi.nlm.nih.gov/pubmed/36359401
http://dx.doi.org/10.3390/biomedicines10112882

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