Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using fructose-fed rats (FFRs), a rat model of MetS...

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Detalles Bibliográficos
Autores principales: Lee, Wei-Chia, Yu, Hong-Ren, Tain, You-Lin, Wu, Kay L.H., Chuang, Yao-Chi, Chan, Julie Y.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687486/
https://www.ncbi.nlm.nih.gov/pubmed/36359236
http://dx.doi.org/10.3390/biomedicines10112716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687486/
https://www.ncbi.nlm.nih.gov/pubmed/36359236
http://dx.doi.org/10.3390/biomedicines10112716

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