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Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using fructose-fed rats (FFRs), a rat model of MetS...

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Detalles Bibliográficos
Autores principales:	Lee, Wei-Chia, Yu, Hong-Ren, Tain, You-Lin, Wu, Kay L.H., Chuang, Yao-Chi, Chan, Julie Y.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687486/ https://www.ncbi.nlm.nih.gov/pubmed/36359236 http://dx.doi.org/10.3390/biomedicines10112716

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