LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport

Primary cilia are antenna-like organelles that regulate growth and development via extracellular signals. However, the molecular mechanisms underlying cilia dynamics, particularly those regulating their disassembly, are not well understood. Here, we show that leucine-rich repeat kinase 1 (LRRK1) pla...

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Detalles Bibliográficos
Autores principales: Hanafusa, Hiroshi, Kedashiro, Shin, Gotoh, Mako, Saitoh, Ko-hei, Inaba, Hironori, Nishioka, Tomoki, Kaibuchi, Kozo, Inagaki, Masaki, Hisamoto, Naoki, Matsumoto, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687541/
https://www.ncbi.nlm.nih.gov/pubmed/36254578
http://dx.doi.org/10.1242/jcs.259999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687541/
https://www.ncbi.nlm.nih.gov/pubmed/36254578
http://dx.doi.org/10.1242/jcs.259999

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